Monday, December 19, 2011

Jimmy Rollins, Phillies Agree On 3-Year Contract: REPORT

PHILADELPHIA ? Jimmy Rollins is bringing his swagger back to the Phillies.

Three people familiar with the negotiations told The Associated Press that Rollins has agreed to a 3-year, $33 million contract with Philadelphia. The deal includes a vesting option for a fourth year.

The people spoke on condition of anonymity Saturday because the agreement is pending a physical.

"Gotta deal with me for 3 (4) more years!" Rollins wrote on Twitter. He also thanked former Philadelphia Eagles safety Brian Dawkins, who tweeted congratulations to Rollins and the Phillies.

Rollins is a three-time All-Star shortstop and the 2007 NL MVP. He has spent his entire career with the Phillies after being selected in the second round of the 1996 amateur draft, and was a free agent for the first time.

Rollins, who turned 33 last month, sought at least a five-year deal. The Phillies didn't want to go that long, and were able to reach an agreement after the market for Rollins lessened.

From the start, Rollins said he wanted to stay in Philadelphia. He has been the heart and soul of a team that has won five consecutive NL East titles and the 2008 World Series. Rollins is undeniably the team leader, a charismatic personality who brings a special confidence to the clubhouse.

Rollins was the guy who boldly proclaimed the Phillies were the team to beat in the division before the 2007 season, even though Philadelphia hadn't won anything in 14 years. He backed that up by having an MVP year, and leading the Phillies to their first postseason appearance since 1993.

Rollins hasn't come close to matching the numbers he put up in 2007 ? .296 average, 30 homers, 94 RBIs, 20 triples, 41 steals. But he remains one of the best defensive players at his position, and is still an offensive threat atop the lineup.

He hit .268 with 16 homers, 63 RBIs and 30 steals this year. He has been plagued by leg injuries in three of the last four years, and played in a career-low 88 games in 2010. He started 135 this year.

Re-signing Rollins had been a top priority for the Phillies. Their biggest move of the offseason was giving former Boston closer Jonathan Papelbon a $50 million, four-year contract.

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Source: http://www.huffingtonpost.com/2011/12/17/jimmy-rollins-phillies-agree-contract-3-year_n_1155842.html

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Sunday, December 18, 2011

Sunni politicians in crosshairs as U.S. leaves Iraq (Reuters)

BAGHDAD (Reuters) ? Iraq's Shi'ite prime minister asked parliament to fire his Sunni deputy, and security sources said an arrest warrant was issued for the Sunni vice president, straining the fragile sectarian coalition on the day the last American troops left.

The last convoy of U.S. soldiers rolled out of Iraq on Sunday ending nearly nine years of war but leaving behind a country in fear that a shaky peace between Shi'ites and Sunnis could collapse, reigniting sectarian slaughter.

Security sources and lawmakers said on Sunday an arrest warrant had been issued for Tareq al-Hashemi, one of Iraq's two vice presidents. They said Sunni and Shi'ite politicians had intervened to stop the arrest from being carried out.

Lawmakers also said on Sunday that a parliamentary official had received Prime Minister Nuri al-Maliki's request overnight for a vote of no confidence against Deputy Prime Minister Saleh al-Mutlaq.

Hashemi and Mutlaq, Iraq's two most-senior Sunni politicians, are leaders of the Iraqiya bloc, a secular group backed by many Sunnis, which joined Maliki's unity government only reluctantly and has long complained of being marginalized.

"The Prime Minister told us that he cannot work with Mutlaq any more.... If this will affect the work and the performance of the cabinet then we will be with him," said Amir al-Kinani, a lawmaker from a Shi'ite bloc.

Iraqiya's parliamentary bloc suspended its participation in parliament on Saturday, accusing Maliki's Shi'ite-led government of concentrating power.

Iraqiya lawmaker Ahmed al-Alwani accused Maliki's authorities of carrying out "political targeting" - using the security forces and justice system against political opponents.

"There must be a way of dealing with these issues, without replacing the celebration of the U.S. withdrawal with the politicization of security matters to target political rivals," he told Reuters.

BODYGUARDS HELD

The security sources, who asked not to be identified, said the arrest warrant for Hashemi was issued after the vice president was linked to terrorist activities by four of his bodyguards, arrested on terrorism charges two weeks ago.

The existence of the arrest warrant for Hashemi could not be confirmed, and Iraqiya state television said Hashemi's office had issued a statement denying it. Reuters was not able to reach Hashemi for comment.

The large scale sectarian violence of 2006-07 has largely subsided, but tensions still simmer close to the surface, with many Sunnis feeling marginalized following the rise to power of majority Shi'ites after the ousting of Saddam Hussein.

In the last years of the U.S. presence, Washington worked hard to keep Sunnis inside the political process to prevent it from unraveling.

Iraq's power-sharing government splits the presidency, the prime minister's post, two vice presidencies and two deputy premierships among Shi'ite, Sunni and Kurdish blocs. But Sunni politicians complain they are kept out of decision making.

Iraqiya, led by former Prime Minister Iyad Allawi, a secular Shi'ite, won the largest number of seats in a March 2010 national election with the support of many Sunnis, but failed to muster a governing majority.

Instead, it joined a unity coalition headed by Maliki, winning posts such as the parliament speakership, vice presidency, and other ministerial positions, but it has since said it has been shunted aside by his lack of cooperation.

(Reporting by Suadad al-Salhy; Editing by Serena Chaudhry and Peter Graff)

Source: http://us.rd.yahoo.com/dailynews/rss/iraq/*http%3A//news.yahoo.com/s/nm/20111218/wl_nm/us_iraq_politics

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Childhood cancer drugs cure now, may cause problems later, research shows

ScienceDaily (Dec. 16, 2011) ? Will a drug used to treat childhood acute lymphoblastic leukemia and other pediatric cancers cause heart problems later in life?

UB associate professor of pharmaceutical sciences, Javier G. Blanco, PhD, who sees his work as a bridge between research and clinical practice, has focused recent efforts on trying to answer this question.

Blanco and colleagues' recent study in the Journal of Clinical Oncology looked for the underlying genetic answers to why some childhood cancer survivors who were treated with anthracylines -- powerful antibiotics like Adriamycin and Daunomycin -- developed cardiomyopathy, such as congestive heart failure, later in life.

"Anthracyclines are effective drugs used to treat a variety of pediatric cancers, they are also used to treat breast cancer and other malignancies in adults," Blanco says. "After cancer, survivors can develop cardiac toxicity anywhere from one year to more than 15 years after the initial chemotherapy with anthracyclines. The window separating the effectiveness of these drugs from their toxicity is narrow. The dosage has to be precise to achieve a therapeutic effect without toxicity."

Blanco explains that the key to individualizing any drug treatment comes down to understanding the way an individual is genetically coded to respond to the drug once it enters the body, and then adjusting the dose accordingly.

Working closely with Smita Bhatia, MD, MPH, chair of the Department of Population Sciences at City of Hope National Medical Center in California and senior author of the study, Blanco and a team of researchers decided to look at how the drug was broken down by enzymes encoded by specific genes.

The study, which began seven years ago, compared DNA genotypes of 170 childhood cancer survivors diagnosed with anthracycline-related cardiomyopathy to a control group of 317 survivors without heart disease.

Using the candidate gene approach, Blanco and his team were able to identify a tiny gene variant related to the risk of cardiotoxicity.

"We pinpointed the genetic difference or polymorphism that makes an enzyme work faster or slower in patients," said Blanco, "slower is better."

They zeroed-in on carbonyl reductases (CBR1 and CBR3) -- two enzymes that break down anthracyclines into cardiotoxic alcohol metabolites. Blanco notes that in mouse models, higher levels of CBRs or faster enzymes dictate higher levels of these metabolites -- and more cardio toxicity.

The research showed that the risk of cardiomyopathy was significantly increased among individuals with two copies of the "G" version of the CBR3 polymorphism when exposed to low-to-moderate doses of anthracycline.

Blanco says that while the results of the study validated the findings of an earlier study in a totally independent cohort of cancer survivors, further study is required.

"We have to be careful," says Blanco. "So far, we are showing an association, not yet causation. Our next step will be to conduct a prospective study -- where we don't study individuals who were exposed to anthracyclines in the past but follow them in real time as they are receiving the drug and after."

What does this mean for children who are taking or have taken anthracyclines?

"If we stop using anthracyclines we will not be able to cure up to 90 percent of the children who suffer from acute lymphoblastic leukemia." Blanco says. "Parents must continue to have their children's health monitored long after the cancer is cured to identify cardiac problems if they develop."

Blanco's research is primarily funded by the National Institute of General Medical Sciences (NIGMS), the Lance Armstrong Foundation and the Leukemia and Lymphoma Society, among many others.

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Source: http://www.sciencedaily.com/releases/2011/12/111216175244.htm

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Saturday, December 17, 2011

Huntsman success in race may rely on independents (The Arizona Republic)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/175795828?client_source=feed&format=rss

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IE 6 deep-sixed in Microsoft browser overhaul

Microsoft

By Suzanne Choney

You may be waiting for the ball to drop for 2012, but Microsoft has another countdown underway that the company deems more urgent: Getting rid of Internet Explorer 6, a decade-old version of the Web browser that seems to have more security holes than Swiss cheese but is still in use by some.

"10 years ago a browser was born. Its name was Internet Explorer 6. Now that we?re in 2011, in an era of modern Web standards, it?s time to say goodbye," the company says on its IE 6 countdown site.?

More than 8 percent of the world still uses IE 6 (in the U.S., it's less than 1 percent), and the company would like to see global usage down to less than 1 percent worldwide. And soon.

(Msnbc.com is a joint venture of Microsoft and NBC Universal.)

To help expedite the farewell (or rather, the execution) of its ancient Web browser, Microsoft says next month it will start to upgrade Windows customers automatically?to the latest version of IE available for their computer.

"This is an important step in helping to move the Web forward," wrote Ryan Gavin, Microsoft's general manager of Internet Explorer business and marketing, on a company blog. "We will start in January for customers in Australia and Brazil who have turned on automatic updating via Windows Update. Similar to our release of IE 9 earlier this year, we will take a measured approach, scaling up over time."

And, he wrote:

For consumers, the safety benefits are one of the key reasons that the industry has been moving towards automatic updates as the norm. This is increasingly important since the biggest online threat these days is socially engineered malware, which typically targets outdated software like Web browsers. The latest Microsoft Security Intelligence Report, which is based on data from over 600 million systems in over 100 countries, is good reading to give you a sense of risks that stem from outdated software.

But what if you don't want to update your version of Internet Explorer? Under a section of the post called "Respecting Customer Choice and Control," Gavin says that IE 8 and IE 9 Automatic Update Blocker toolkits "prevent automatic upgrades of IE for Windows customers who do not want them. Of course, we firmly believe that IE 9 is the most compelling browser for business customers, and we want them to make the decision to upgrade at their convenience."

Customers "who have declined previous installations of IE 8 or IE 9 through Windows Update will not be automatically updated," he wrote. "Customers have the ability to uninstall updates and continue to receive support for the version of IE that came with their copy of Windows. And similar to organizations, consumers can block the update all together and upgrade on their own. Finally, future versions of IE will provide an option in the product for consumers to opt out of automatic upgrading."

But say good-bye to IE 6 if you have it. And some of you may already be saying good-bye to IE in general. Google's Chrome appears to be gaining more of a foothold among users, as IE's market share continues to drop.

Related stories:

Check out Technolog, Gadgetbox, Digital Life and In-Game on?Facebook,?and on Twitter, follow Suzanne Choney.

Source: http://technolog.msnbc.msn.com/_news/2011/12/15/9471072-ie-6-deep-sixed-in-microsoft-browser-overhaul

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Friday, December 16, 2011

French court convicts Chirac of corruption

(AP) ? A French court found former President Jacques Chirac guilty of embezzling public funds to illegally finance the conservative party he long led, in a historic verdict Thursday with repercussions for his legacy and France's political elite.

Chirac, a savvy world diplomat and icon of France's ruling establishment for decades, will not go behind bars but was handed a two-year suspended sentence that goes on his criminal record. Anti-corruption crusaders, long frustrated by dirty dealings in the French political machine, rejoiced at the conviction.

He's the first former French head of state to face prosecution since the World War II era. But the 79-year-old former leader did not take part in the trial, after doctors determined that he suffers severe memory lapses.

The court said Thursday it had found Chirac guilty in two related cases involving fake jobs created at the RPR party, which he led during his 1977-1995 tenure as Paris mayor. He was convicted of embezzling public funds, abuse of trust, and illegal conflict of interest.

Chirac repeatedly denied wrongdoing. It took years to get him to trial because he enjoyed immunity from prosecution during his 1995-2007 presidential tenure, during which he led France into the shared euro currency and became the global champion of opposition to the U.S.-led invasion of Iraq.

The court said it took into account his age, health and status as a former head of state when determining the light sentence.

Unusually, the prosecutor had requested that Chirac and the nine other defendants in the complex two-part case be acquitted, saying not enough evidence proved intentional corruption. The court disagreed, saying his guilt results "from long-standing and reiterated practices" of illegal party financing.

Chirac's adopted daughter fought back tears as she lamented the ruling.

"The justice system has been very severe, but this is a fair and independent justice system. For the family, it's a great pain we have to accept," said Chirac's adopted daughter Anh Dao Traxel, her voice cracking with emotion as she spoke to reporters outside the courtroom.

"I think this decision is too, too severe for him and our family has more than ever to show solidarity and be supportive, for his health for the rest of his life," said Traxel, a former Vietnamese boat person. Chirac and his wife formally adopted Traxel after she came to Paris in 1979.

Chirac spokeswoman Benedicte Brissart declined to comment immediately, saying time was needed to go over the decision.

Chirac lawyer Georges Kiejman called the ruling disappointing and said he expected a decision later Thursday on whether Chirac would appeal.

"We have to take a step back and read this ruling, we have to speak of course with the main person involved (Chirac), and we will know tonight if he accepts this decision," Kiejman said. "What I hope is that this ruling doesn't change in any way the deep affection the French feel legitimately for Jacques Chirac."

The ruling is certain to bruise Chirac's public image. Leaving office in 2007 did wonders for his popularity: while polls showed that he was unpopular in his final years as president, those numbers soared afterward ? and even today, the avuncular former leader, who now focuses on charitable work, has been one of France's most popular public figures.

Critics had pushed for years to see Chirac answer charges of illegal party financing, frustrated by his presidential immunity and a sense that the political machine would never let the sensitive trial come to pass.

Jerome Karsenti, a lawyer for the anti-corruption group Anticor, which had argued against Chirac as a civil party to the case, said the reverberations could be widespread for France's political elites.

"This is a strong message from the court ? a message to all politicians of responsibility. It's also proof of a mature and transparent democracy that is today able to make a distinction and try a former president," Karsenti said.

"I see it as a historic and very important decision for the future of French democracy," he said.

The latest baring of France's underworld of back-room cronyism, corruption and political wrongdoing could loom large in voters minds as the French cast ballots in presidential and legislative elections next year.

The party that succeeded the RPR, President Nicolas Sarkozy's UMP party, and the opposition Socialist Party have seen their share of scandal recently. Two longtime Sarkozy allies have been targeted since September in a case of suspected kickbacks in a 1990s French defense deal with Pakistan. Sarkozy served as budget minister at the time, but his office and allies insist he was not involved.

In Thursday's ruling, the court found that 19 totally or partially fake jobs were created to benefit Chirac. "The case and the debates established that Jacques Chirac was the initiator and principal author of crimes of abuse of trust, embezzling and illegal conflict of interest," the ruling said.

A career politician, Chirac was a debonair master of the workings of public office. He modeled himself after longtime French leader Charles de Gaulle and was nicknamed "Le Bulldozer" early in his career for his determination and ambition.

France's last leader with memories of World War II, Chirac was the first to acknowledge the nation's responsibility for the deportation of Jews during the Holocaust. But he struggled to achieve reforms to the regulated economy and failed to defuse tensions between police and minority youth that exploded into riots in 2005.

___

Jamey Keaten in Paris contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2011-12-15-EU-France-Chirac-Trial/id-c6650f94716b47dab4a461ea305a9a18

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